Tired of dealing with lab billing errors and delayed insurance payments? Searching for a laboratory billing partner that can boost your revenue and efficiency? In today’s complex healthcare environment, accurate laboratory billing is crucial for maintaining cash flow, ensuring compliance, and minimizing claim denials. Each year, an estimated $10–12 billion in laboratory claims remain unpaid, with nearly 55% of denied claims left unaddressed.
Specialized billing companies have become essential partners, helping labs navigate coding complexities, reduce administrative burdens, and optimize financial performance. This guide highlights the top laboratory billing service providers in the USA, helping you find the right solution to streamline your revenue cycle management.
1. Nexus io
Nexus IO, a trusted medical billing company based in Phoenix, Arizona, specializes in expert laboratory billing services. Established in 2025, Our team has over 10 years of healthcare billing experience, optimizing revenue cycles for laboratories nationwide. We provide compliant medical billing, accurate claim processing, and revenue cycle management for diagnostic labs nationwide. Their proven results include 90% collection rate, 88% clean claim rate, and 30% A/R reduction. Partner with us for optimized reimbursements and reduced administrative burdens.
2. Lab Billing
Lab Billing company established in 2015 and headquartered in Williamsport, Pennsylvania, this mid-sized company (51–200 employees) specializes in laboratory billing services. The company delivers tailored billing solutions that boost lab revenue by up to 29% and reduce denials with a 99% clean claims rate. Their expert team ensures accurate coding, fast claim submissions, compliance, and complete revenue cycle management for growth-focused laboratories.
3. AltuMED
AltuMED is a medical billing company based in Southfield, Michigan, with a team of 11–50 employees. Since 2011, they have been helping labs manage their billing smoothly. They offer custom lab billing services, using accurate coding, electronic claim submission, and smart reporting tools. AltuMED works with all types of labs like genetic, toxicology, pathology, and molecular labs to reduce claim denials, improve cash flow, and follow all rules, so labs can focus on patient care.
4. BillingParadise
BillingParadise started in 2004 and is based in Atlanta, Georgia. It has 201 to 500 employees. The company helps labs with their billing using smart AI technology. They work with different labs like clinical, pathology, molecular, and toxicology labs. BillingParadise has a lot of experience and helps labs get fewer claim denials 24% less, get paid faster 50% quicker, and have almost all claims accepted the first time 98%.
They follow strict rules to keep information safe. Their services include checking claims for errors, tracking payments in real-time, connecting with lab systems, and offering expert help anytime. This makes BillingParadise a trusted helper for labs to manage their billing well.
5. Prolis.
Prolis, founded in 2009, is headquartered in New Brunswick, New Jersey, with a team of 11-50 employees. They specialize in comprehensive laboratory medical billing services across the USA, serving small to large practices. With over 10 years of experience, ASSC achieves a 98% first-pass claim acceptance rate 3% above industry average and maintains less than 10% denial rates.
They use 80% electronic submissions, advanced claim scrubbing technology, and provide detailed financial reporting. Services include laboratory billing, laboratory coding, laboratory credentialing, laboratory denial management, laboratory accounts receivable management, and revenue cycle management, ensuring faster payments and optimized practice revenue.
6. RCM Matter
RCM Matter, started providing laboratory RCM 2016 and based in Glendale, CA, has 501-1,000 employees. They have proven their lab billing services work well, earning an A+ rating from BBB and 4-star reviews from real customers. RCM Matter offers tailored laboratory billing solutions for a wide range of diagnostic tests.
Their services include Blood Test Billing with accurate coding and faster reimbursements, Urine Analysis Billing for timely claim submissions, and Genetic Testing Billing with compliant processing of complex panels. They also specialize in Pathology Billing for lab diagnostics, Molecular Testing Billing with streamlined coding for advanced procedures, and COVID-19 Test Billing for fast, accurate payments during high-demand periods.
7. Physicians Group Management (PGM Billing)
PGM Billing established in 1981 and headquartered in Lyndhurst, New Jersey. PGM Billing is a mid-sized company with 51-200 employees. It was among the Inc. 5000 in 2011. PGM handles laboratory billing services, assisting laboratories in filing claims, correcting denials, improving coding, and following up on payments. For over 30 years, PGM has helped laboratories receive more payment from insurance, reduce billing errors, stay compliant, and access real-time reports through an easy-to-use interface and hands-on support.
8. Docs Medical Billing
Docs Medical Billing Company, founded in 2015, is an Madera, California-based firm with from 201 to 500 people on staff. It specializes in laboratory billing with a focus on improving revenue cycle management by accurate coding and fast claim approvals, thereby bringing down denials and increasing reimbursements for labs in all of fifty states.
Their specialty includes pathology, toxicology, molecular, and clinical lab billing. They streamline lab billing for better financial performance with a 99% first pass and 98% clean claim rates. This is corroborated by a strong 5.0 rating on Google based on 14 reviews, signifying high client satisfaction.
9. Med USA
Med USA is a company based in Sandy, UT, and started in 1979. It has 201–500 employees and focuses on laboratory billing services. They provide flexible laboratory billing and revenue cycle solutions to help labs get paid faster and increase their income.
With a 99% first-pass rate and 18% average revenue growth, Med USA helps find laboratory billing mistakes, lost revenue, and delays in follow-ups. Their team also handles compliance, charge posting, patient calls, and insurance work. Labs can trust them to make billing easier and more accurate. They have a 4.1 rating on Google with 14 reviews.
10. Phytest
Founded in 1998 and headquartered in Atlanta, GA, Phytest provides comprehensive laboratory medical billing services nationwide. Leveraging its proprietary Phytest Atlas platform, it offers automated claim scrubbing, LIS/LIMS integration, insurance verification, denial management, and custom financial reporting.
With a dedicated U.S.-based patient services team, in-house development, and compliance with HIPAA and federal regulations, Phytest ensures faster reimbursements and fewer errors. Serving all lab specialties, Phytest delivers end-to-end RCM solutions with no startup fees and 11+ years average client retention.
Bottom Line
This list was made by looking at important things like how many claims get paid the first time, how much money the company helps bring in, how long they’ve worked in billing, how many clients stay with them, and if they follow the rules. Picking the right lab billing company can really help doctors by stopping claim denials, getting payments faster, and making more money. Don’t choose a company that doesn’t know much about lab billing, hides their prices, doesn’t follow rules, or doesn’t give reports. Choose a company with good laboratory billing experience, smart tools, great service, and a history of helping others do well.
