A drug claim can be clean in every way right code, right units, solid documentation and still bounce back the moment a single two-character modifier is missing.
That's the CO 226 denial code in a nutshell. It's one of the most frustrating denials in medical billing because the underlying service is rarely the problem.
According to Experian Health's 2025 State of Claims survey, 41% of healthcare providers now face denial rates exceeding 10%, and that number has climbed every year since 2022
Every year, addiction treatment facilities across the United States lose millions in legitimate reimbursements, not because their clinical care falls short.
